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Abstract The advent of 3D printing has facilitated the rapid fabrication of microfluidic devices that are accessible and cost‐effective. However, it remains a challenge to fabricate sophisticated microfluidic devices with integrated structural and functional components due to limited material options of existing printing methods and their stringent requirement on feedstock material properties. Here, a multi‐materials multi‐scale hybrid printing method that enables seamless integration of a broad range of structural and functional materials into complex devices is reported. A fully printed and assembly‐free microfluidic biosensor with embedded fluidic channels and functionalized electrodes at sub‐100 µm spatial resolution for the amperometric sensing of lactate in sweat is demonstrated. The sensors present a sensitive response with a limit of detection of 442 nmand a linear dynamic range of 1–10 mm, which are performance characteristics relevant to physiological levels of lactate in sweat. The versatile hybrid printing method offers a new pathway toward facile fabrication of next‐generation integrated devices for broad applications in point‐of‐care health monitoring and sensing. 

Abstract The development of new materials and their compositional and microstructural optimization are essential in regard to next-generation technologies such as clean energy and environmental sustainability. However, materials discovery and optimization have been a frustratingly slow process. The Edisonian trial-and-error process is time consuming and resource inefficient, particularly when contrasted with vast materials design spaces¹. Whereas traditional combinatorial deposition methods can generate material libraries^2,3, these suffer from limited material options and inability to leverage major breakthroughs in nanomaterial synthesis. Here we report a high-throughput combinatorial printing method capable of fabricating materials with compositional gradients at microscale spatial resolution. In situ mixing and printing in the aerosol phase allows instantaneous tuning of the mixing ratio of a broad range of materials on the fly, which is an important feature unobtainable in conventional multimaterials printing using feedstocks in liquid–liquid or solid–solid phases^4–6. We demonstrate a variety of high-throughput printing strategies and applications in combinatorial doping, functional grading and chemical reaction, enabling materials exploration of doped chalcogenides and compositionally graded materials with gradient properties. The ability to combine the top-down design freedom of additive manufacturing with bottom-up control over local material compositions promises the development of compositionally complex materials inaccessible via conventional manufacturing approaches. 

Abstract Large igneous provinces (LIPs) typically form in one short pulse of ∼1–5 Ma or several punctuated ∼1–5 Ma pulses. Here, our 25 new 40Ar/39Ar plateau ages for the main construct of the Kerguelen LIP—the Cretaceous Southern and Central Kerguelen Plateau, Elan Bank, and Broken Ridge—show continuous volcanic activity from ca. 122 to 90 Ma, a long lifespan of >32 Ma. This suggests that the Kerguelen LIP records the longest, continuous high-magma-flux emplacement interval of any LIP. Distinct from both short-lived and multiple-pulsed LIPs, we propose that Kerguelen is a different type of LIP that formed through long-term interactions between a mantle plume and mid-ocean ridge, which is enabled by multiple ridge jumps, slow spreading, and migration of the ridge. Such processes allow the transport of magma products away from the eruption center and result in long-lived, continuous magmatic activity.